Clomid – Understanding Clomiphene Citrate

Clomiphene Citrate or Clomid as it is more commonly known as is a Selective Estrogen Receptor Modulator (SERMs), specifically as an anti estrogen. Other anti estrogen known as Aromatase Inhibitors (AI) are aromasin (Exemestane) and arimidex (Anastrozole). The difference between AI and SERMs is how they deal with controlling estrogen. AI such as Aromasin and Arimidex will eliminate estrogen in the blood where as SERMs will block estrogen at the receptor sites by taking the place of estrogen in the receptor sites so estrogen can not bind. Clomid is very close to Nolvadex in that both are SERMs however Clomid has a weaker ability to bind to receptor sites in breast tissue then Nolvadex does. Clomid’s use in medicine is that of a ovulation stimulation for women.

In men Clomid will trigger the the Luteinizing Hormone (LH) and the Follicle Stimulating Hormone (FSH) to signal the testes to increase production of testosterone. In females the same happens but it will trigger the release of eggs from the ovaries which in turn leads to a greater chance of contraception. In the case of male steroid users, clomid is an effective anti estrogen to prevent gynecomastia or the development of breast tissue as well as increasing the production of LH and FSH which increases testosterone production. This is highly important for individuals who wish to restore proper hormone function post cycle known as Post Cycle Therapy (PCT). Clomid has a long standing history in PCT protocols as well as male and female fertility.

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